Pharmacology practice questions

Question 1

A drug acting as a Gβγ subunit inhibitor would most likely affect:

Accepted Answer

Downstream signaling from GPCRs

Answer

Ligand binding

Answer

Receptor dimerization

Answer

Adenylyl cyclase production

Question 2

An allosteric modulator of a GPCR acts by:

Accepted Answer

Binding a separate site to enhance or reduce response

Answer

Blocking the orthosteric site

Answer

Reversibly binding ATP

Answer

Degrading the receptor

Question 3

GPCRs are characterized structurally by:

Accepted Answer

Seven transmembrane helices

Answer

Single transmembrane domain

Answer

Four subunit pentamer

Answer

Intracellular kinase activity

Question 4

Buprenorphine is safer in overdose than morphine because:

Accepted Answer

It is a partial agonist with a ceiling effect

Answer

It is a competitive antagonist

Answer

It has higher potency

Answer

It does not bind to opioid receptors

Question 5

Which of the following describes a partial agonist?

Accepted Answer

It activates receptors but produces a submaximal response

Answer

It cannot activate any receptors

Answer

It fully activates receptors like a full agonist

Answer

It inhibits all receptor activity

Question 6

In a dose-response curve, a lower EC50 value indicates:

Accepted Answer

Higher potency

Answer

Higher toxicity

Answer

Lower affinity

Answer

Greater metabolism

Question 7

Which of the following is an example of allosteric modulation?

Accepted Answer

Ligand binding to a separate site enhancing receptor activity

Answer

Morphine binding to the µ-opioid receptor

Answer

Drug binding to the same site as the endogenous ligand

Answer

Ligand binding causing receptor internalization

Question 8

Which parameter describes how tightly a drug binds to its receptor?

Accepted Answer

Affinity

Answer

Efficacy

Answer

Potency

Answer

Toxicity

Question 9

What type of molecule binds a receptor and triggers a biological response?

Accepted Answer

Agonist

Answer

Antagonist

Answer

Ligand

Answer

Inhibitor

Question 10

Why is the concept of 'druggability' important in pharmacology?

Accepted Answer

It indicates the ability to modulate a target with a small molecule

Answer

It helps identify non-protein targets

Answer

It predicts off-target effects

Answer

It estimates drug costs

Pharmacology practice questions

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Pharmacology practice questions

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