USMLE (United States Medical Licensing Examination) practice questions

Question 1

A 65-year-old man presents with chest pain and shortness of breath. An ECG reveals ST-segment elevation in leads V1-V4. Which coronary artery is most likely occluded?

Accepted Answer

Left anterior descending artery

Answer

Left circumflex artery

Answer

Right coronary artery

Answer

Posterior descending artery

Question 2

A 28-year-old woman presents with a sudden onset of shortness of breath and pleuritic chest pain. She has a history of deep vein thrombosis. Which is the most likely diagnosis?

Accepted Answer

Pulmonary embolism

Answer

Pneumonia

Answer

Asthma exacerbation

Answer

Pneumothorax

Question 3

A 45-year-old man with a history of chronic alcohol use presents with severe abdominal pain radiating to the back. Laboratory tests show elevated serum lipase and amylase. What is the most likely diagnosis?

Accepted Answer

Acute pancreatitis

Answer

Cholecystitis

Answer

Peptic ulcer disease

Answer

Hepatitis

Question 4

A 60-year-old woman presents with progressive weakness, muscle atrophy, and fasciculations. Her deep tendon reflexes are brisk. Which condition is most consistent with these findings?

Accepted Answer

Amyotrophic lateral sclerosis

Answer

Multiple sclerosis

Answer

Guillain-Barré syndrome

Answer

Myasthenia gravis

Question 5

A 35-year-old woman presents with fatigue, weight gain, and cold intolerance. Laboratory results show a decreased free T4 and elevated TSH. What is the most likely diagnosis?

Accepted Answer

Hashimoto's thyroiditis

Answer

Graves' disease

Answer

Subacute thyroiditis

Answer

Pituitary adenoma

Question 6

A 40-year-old man presents with fever, night sweats, and weight loss. He has a history of IV drug use. A chest X-ray shows cavitary lesions in the upper lobes. What is the most likely organism?

Accepted Answer

Mycobacterium tuberculosis

Answer

Staphylococcus aureus

Answer

Aspergillus fumigatus

Answer

Pseudomonas aeruginosa

Question 7

A 28-year-old woman presents with fatigue and pallor. Laboratory studies reveal microcytic anemia with elevated serum ferritin. What is the most likely cause of her anemia?

Accepted Answer

Anemia of chronic disease

Answer

Iron deficiency anemia

Answer

Thalassemia

Answer

Lead poisoning

Question 8

A 25-year-old man presents with a 2-week history of depressed mood, anhedonia, and insomnia. He has no history of manic episodes. What is the most likely diagnosis?

Accepted Answer

Major depressive disorder

Answer

Bipolar disorder

Answer

Dysthymia

Answer

Cyclothymia

Question 9

A 50-year-old man presents with hematuria and flank pain. Imaging reveals a mass in the left kidney. Which of the following is the most likely diagnosis?

Accepted Answer

Renal cell carcinoma

Answer

Polycystic kidney disease

Answer

Pyelonephritis

Answer

Hydronephrosis

Question 10

A 30-year-old woman presents with joint pain and a malar rash. Laboratory studies reveal positive ANA and anti-dsDNA antibodies. What is the most likely diagnosis?

Accepted Answer

Systemic lupus erythematosus

Answer

Rheumatoid arthritis

Answer

Sjogren's syndrome

Answer

Scleroderma

USMLE (United States Medical Licensing Examination) practice questions

Question stream

Discussion

Manage your cookie preferences

Loading subject practice

Loading Brainliest

Loading subject practice

USMLE (United States Medical Licensing Examination) practice questions

Question stream

Discussion

Practice overview