Practice sessionHEALTHCARE & MEDICAL EXAMSMEDICAL LICENSING
USMLE (United States Medical Licensing Examination) Practice Exam 07
Practice exam for USMLE (United States Medical Licensing Examination).
Active sessionUSMLE overviewUSMLE Step 1USMLE Step 2 CKUSMLE Step 3medical licensing exam+1
Question 1 of 760%
Time remaining180:00
Attempts allowedUnlimited
Difficulty mixE • M • H
Question 1
MEDIUMA 62-year-old man with long-standing hypertension is started on a medication that decreases angiotensin II formation. Two weeks later, he develops a persistent dry cough. Which change in vasoactive mediators most directly explains this adverse effect?
ACE inhibitors decrease conversion of angiotensin I to angiotensin II and also inhibit bradykinin breakdown, leading to bradykinin accumulation that can cause cough and angioedema. Decreased endothelin-1 is not the mechanism of ACE inhibitor cough; increased aldosterone would be opposite of ACE inhibition.
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